Article
Perfluorocarbons and Gilbert syndrome (phenotype) in the C8 Health Study Population.
Environmental research - 1 Nov 2014
Fan Hongmin, Ducatman Alan, Zhang Jianjun
Abstract excerpt
BACKGROUND: Gilbert syndrome (GS) is an inherited defect of bilirubin conjugation, most commonly caused by a gene mutation for the enzyme UGT1A. GS is known to affect the metabolism and excretion of drugs and xenobiotics. Perfluorocarbon compounds (PFCs) are bio-persistent environmental contaminants that affect metabolic regulation. In this study, we examined the associations of GS phenotype and serum PFCs in the...
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