Article
[The reverse effects of allitridum on sodium current decrease caused by SCN5A-F1473S mutation].
Yao xue xue bao = Acta pharmaceutica Sinica - 1 Dec 2016
Cai Zhong-qi, Li Wan-peng, Chen Xi, Zhu Chao, Xie Xiao-ting, Liu Li, Zhao Ying, Huang Yan, Li Yang
Abstract excerpt
This study was designed to test the allitridum (All) activity in correction of sodium current decrease caused by SCN5A-F1473S mutation in HEK293 cells. The result may provide a theoretical basis for screening of new drugs in the treatment of Brugada syndrome. We transferred SCN5A-F1473S channel plasmids into HEK293 cells in a transient transfection. All was administrated acutely and chronically using...
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