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Article

Impact of individual extracellular proteases on Staphylococcus aureus biofilm formation in diverse clinical isolates and their isogenic sarA mutants.

MicrobiologyOpen - 1 Dec 2014

Loughran Allister J, Atwood Danielle N, Anthony Allison C, Harik Nada S, Spencer Horace J, Beenken Karen E, Smeltzer Mark S

Abstract excerpt

We demonstrate that the purified Staphylococcus aureus extracellular proteases aureolysin, ScpA, SspA, and SspB limit biofilm formation, with aureolysin having the greatest impact. Using protease-deficient derivatives of LAC, we confirmed that this is due to the individual proteases themselves. Purified aureolysin, and to a lesser extent ScpA and SspB, also promoted dispersal of an established biofilm. Mutation...

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Identifiers

PMID: 25257373
DOI: 10.1002/mbo3.214
PMCID: PMC4263513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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