Article
Genome-wide exploration identifies sex-specific genetic effects of alleles upstream NPY to increase the risk of severe periodontitis in men.
Journal of clinical periodontology - 1 Dec 2014
Freitag-Wolf Sandra, Dommisch Henrik, Graetz Christian, Jockel-Schneider Yvonne, Harks Inga, Staufenbiel Ingmar, Meyle Joerg, Eickholz Peter, Noack Barbara, Bruckmann Corinna, Gieger Christian, Jepsen Søren, Lieb Wolfgang, Schreiber Stefan, König Inke R, Schaefer Arne S
Abstract excerpt
AIM: Periodontitis (PD) is influenced by genetic as well as lifestyle and socio-economic factors. Epidemiological studies show that men are at greater risk of severe forms of PD, suggesting interplay between sex and genetic factors. We aimed to systematically analyse patients with aggressive periodontitis (AgP) for gene-sex interactions. MATERIALS AND METHODS: Three hundred and twenty-nine German AgP cases and...
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