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Article

CC chemokine receptor-like 1 functions as a tumour suppressor by impairing CCR7-related chemotaxis in hepatocellular carcinoma.

The Journal of pathology - 1 Mar 2015

Shi Jie-Yi, Yang Liu-Xiao, Wang Zhi-Chao, Wang Ling-Yan, Zhou Jian, Wang Xiao-Ying, Shi Guo-Ming, Ding Zhen-Bin, Ke Ai-Wu, Dai Zhi, Qiu Shuang-Jian, Tang Qi-Qun, Gao Qiang, Fan Jia

Abstract excerpt

Atypical chemokine receptors (ACRs) have been discovered to participate in the regulation of tumour behaviour. Here we report a tumour-suppressive role of a novel ACR member, CC chemokine receptor like 1 (CCRL1), in human hepatocellular carcinoma (HCC). Both mRNA and protein expressions of CCRL1 correlated with the malignant phenotype of HCC cells and were significantly down-regulated in tumour tissue compared...

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Source

Identifiers

PMID: 25255875
DOI: 10.1002/path.4450

Genes

CCR7
CCL19
CCL21
ACR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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