Article
Chemokine receptor CCR7 enhances intrahepatic and lymphatic dissemination of human hepatocellular cancer.
Oncology reports - 1 Jul 2006
Schimanski Carl C, Bahre Rüdiger, Gockel Ines, Junginger Theodor, Simiantonaki Nektaria, Biesterfeld Stefan, Achenbach Tobias, Wehler Thomas, Galle Peter R, Moehler Markus
Abstract excerpt
Despite many pathophysiological analyses, the process of tumor dissemination of hepatocellular carcinoma (HCC) remains vague. In diverse tumor entities, expression of the chemokine receptor, CCR7, has been linked to tumor dissemination and poor prognosis. Therefore, we evaluated, whether CCR7 exerts similar effects in human HCC. CCR7 expression analysis was performed in vitro on human hepatoma cell lines (Huh7,...
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