Article
Senescence is accelerated through donor cell specificity in cloned pigs.
International journal of molecular medicine - 1 Aug 2012
Jeon Hyun Yong, Jeong Yeon Woo, Kim Yeon Wook, Jeong Yeon Ik, Hossein Shamim M, Yang Hyun, Hyun Sang Hwan, Jeung Eui-Bae, Hwang Woo Suk
Abstract excerpt
Animals cloned by somatic cell nuclear transfer (SCNT) sometimes have abnormalities that result in large offspring syndrome or early death during gestation due to respiratory and metabolic defects. We cloned pigs using two sources of donor cells and observed phenotypic anomalies in three pigs cloned from one type of cell, s-pig fetal fibroblasts. These animals had...
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