Article
Single-cell analyses of regulatory network perturbations using enhancer-targeting TALEs suggest novel roles for PU.1 during haematopoietic specification.
Development (Cambridge, England) - 1 Oct 2014
Wilkinson Adam C, Kawata Viviane K S, Schütte Judith, Gao Xuefei, Antoniou Stella, Baumann Claudia, Woodhouse Steven, Hannah Rebecca, Tanaka Yosuke, Swiers Gemma, Moignard Victoria, Fisher Jasmin, Hidetoshi Shimauchi, Tijssen Marloes R, de Bruijn Marella F T R, Liu Pentao, Göttgens Berthold
Abstract excerpt
Transcription factors (TFs) act within wider regulatory networks to control cell identity and fate. Numerous TFs, including Scl (Tal1) and PU.1 (Spi1), are known regulators of developmental and adult haematopoiesis, but how they act within wider TF networks is still poorly understood. Transcripti...
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