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Article

Optimization of the oligonucleotide ligation assay for the detection of nevirapine resistance mutations in Zimbabwean Human Immunodeficiency Virus type-1 subtype C.

Journal of virological methods - 15 Dec 2014

Mutsvangwa J, Beck I A, Gwanzura L, Manhanzva M T, Stranix-Chibanda L, Chipato T, Frenkel L M

Abstract excerpt

An oligonucleotide ligation assay (OLA) designed to detect Human Immunodeficiency Virus type-1 (HIV)-drug-resistance to the nevirapine (NVP) selected mutations K103N, Y181C, V106M and G190A was used to evaluate 200 archived dried blood spots (DBS) from infected infants participating in the Zimbabwean Early Infant Diagnosis (EID) Program. Consensus sequencing of specimens with indeterminate OLA results was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25239368
DOI: 10.1016/j.jviromet.2014.09.005
PMCID: PMC4363305

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