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Article

The key to predicting the stability of protein mutants lies in an accurate description and proper configurational sampling of the folded and denatured states.

Biochimica et biophysica acta - 1 May 2015

Eichenberger Andreas P, van Gunsteren Wilfred F, Riniker Sereina, von Ziegler Lukas, Hansen Niels

Abstract excerpt

BACKGROUND: The contribution of particular hydrogen bonds to the stability of a protein fold can be investigated experimentally as well as computationally by the construction of protein mutants which lack particular hydrogen-bond donors or acceptors with a subsequent determination of their structural stability. However, the comparison of experimental data with computational results is not straightforward. One of...

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Identifiers

PMID: 25239199
DOI: 10.1016/j.bbagen.2014.09.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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