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PCSK9 polymorphism in a Tunisian cohort: identification of a new allele, L8, and association of allele L10 with reduced coronary heart disease risk.

Molecular and cellular probes - 1 Feb 2015

Slimani Afef, Hrira Mohamed Yahia, Najah Mohamed, Jomaa Walid, Maatouk Faouzi, Hamda Khaldoun Ben, Abifadel Marianne, Rabès Jean-Pierre, Boileau Catherine, Rouis Mustapha, Slimane Mohamed Naceur, Varret Mathilde

Abstract excerpt

The c.61_63dupCTG (L10) allele of rs72555377 polymorphism in PCSK9 has been reported to be associated with low-density lipoprotein-cholesterol (LDL-C) levels and with a decreased risk of coronary artery disease (CAD). We investigated the effect of two known alleles for rs72555377, L10 and L11, on the risk of CAD in a Tunisian cohort (218 patients diagnosed by angiography and 125 control subjects). Two subgroups...

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Source

Identifiers

PMID: 25239117
DOI: 10.1016/j.mcp.2014.09.001

Genes

CAD
PCSK9

Variants

rs72555377

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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