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Article

Regulation of bone morphogenetic protein 9 (BMP9) by redox-dependent proteolysis.

The Journal of biological chemistry - 7 Nov 2014

Wei Zhenquan, Salmon Richard M, Upton Paul D, Morrell Nicholas W, Li Wei

Abstract excerpt

BMP9, a member of the TGFβ superfamily, is a homodimer that forms a signaling complex with two type I and two type II receptors. Signaling through high-affinity activin receptor-like kinase 1 (ALK1) in endothelial cells, circulating BMP9 acts as a vascular quiescence factor, maintaining endothelial homeostasis. BMP9 is also the most potent BMP for inducing osteogenic signaling in mesenchymal stem cells in vitro...

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Source

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Identifiers

PMID: 25237187
DOI: 10.1074/jbc.M114.579771
PMCID: PMC4223318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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