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Article

A systems approach to predict oncometabolites via context-specific genome-scale metabolic networks.

PLoS computational biology - 1 Sept 2014

Nam Hojung, Campodonico Miguel, Bordbar Aarash, Hyduke Daniel R, Kim Sangwoo, Zielinski Daniel C, Palsson Bernhard O

Abstract excerpt

Altered metabolism in cancer cells has been viewed as a passive response required for a malignant transformation. However, this view has changed through the recently described metabolic oncogenic factors: mutated isocitrate dehydrogenases (IDH), succinate dehydrogenase (SDH), and fumarate hydratase (FH) that produce oncometabolites that competitively inhibit epigenetic regulation. In this study, we demonstrate in...

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Identifiers

PMID: 25232952
DOI: 10.1371/journal.pcbi.1003837
PMCID: PMC4168981

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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