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Article

Finding new hits in neglected disease projects: target or phenotypic based screening?

Current topics in medicinal chemistry - 1 Jan 2011

Gilbert Ian H, Leroy Didier, Frearson Julie A

Abstract excerpt

In this article, we discuss the merits of both target-based and phenotypic screening strategies to find starting points for drug discovery projects in neglected tropical disease including: human African trypanosomiasis, Chagas disease, leishmaniasis and malaria. Technological advances now mean that it is possible to undertake high quality screens against isolated molecular targets at considerable scale. However...

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PMID: 21401505
DOI: 10.2174/156802611795429176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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