Giardial triosephosphate isomerase as possible target of the cytotoxic effect of omeprazole in Giardia lamblia.

doi:10.1128/AAC.02900-14

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Giardial triosephosphate isomerase as possible target of the cytotoxic effect of omeprazole in Giardia lamblia.

Antimicrobial agents and chemotherapy - 1 Dec 2014

Reyes-Vivas Horacio, de la Mora-de la Mora Ignacio, Castillo-Villanueva Adriana, Yépez-Mulia Lilian, Hernández-Alcántara Gloria, Figueroa-Salazar Rosalia, García-Torres Itzhel, Gómez-Manzo Saúl, Méndez Sara T, Vanoye-Carlo América, Marcial-Quino Jaime, Torres-Arroyo Angélica, Oria-Hernández Jesús, Gutiérrez-Castrellón Pedro, Enríquez-Flores Sergio, López-Velázquez Gabriel

Abstract excerpt

Giardiasis is highly prevalent in the developing world, and treatment failures with the standard drugs are common. This work deals with the proposal of omeprazole as a novel antigiardial drug, focusing on a giardial glycolytic enzyme used to follow the cytotoxic effect at the molecular level. We used recombinant technology and enzyme inactivation to demonstrate the capacity of omeprazole to inactivate giardial...

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PMID: 25223993
DOI: 10.1128/AAC.02900-14
PMCID: PMC4249547

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