Giardial triosephosphate isomerase as possible target of the cytotoxic effect of omeprazole in Giardia lamblia.

doi:10.1128/AAC.02900-14

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Giardial triosephosphate isomerase as possible target of the cytotoxic effect of omeprazole in Giardia lamblia.

Antimicrobial agents and chemotherapy - 1 Dec 2014

Reyes-Vivas Horacio, de la Mora-de la Mora Ignacio, Castillo-Villanueva Adriana, Yépez-Mulia Lilian, Hernández-Alcántara Gloria, Figueroa-Salazar Rosalia, García-Torres Itzhel, Gómez-Manzo Saúl, Méndez Sara T, Vanoye-Carlo América, Marcial-Quino Jaime, Torres-Arroyo Angélica, Oria-Hernández Jesús, Gutiérrez-Castrellón Pedro, Enríquez-Flores Sergio, López-Velázquez Gabriel

Abstract excerpt

Giardiasis is highly prevalent in the developing world, and treatment failures with the standard drugs are common. This work deals with the proposal of omeprazole as a novel antigiardial drug, focusing on a giardial glycolytic enzyme used to follow the cytotoxic effect at the molecular level. We used recombinant technology and enzyme inactivation to demonstrate the capacity of omeprazole to inactivate giardial...

Topics

Albendazole
Antiprotozoal Agents
Axenic Culture
Cysteine
Dose-Response Relationship, Drug
Drug Resistance
Enzyme Inhibitors
Escherichia coli

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression

Giardia lamblia

Humans

Metronidazole

Mutation

Nitro Compounds

Omeprazole

Parasitic Sensitivity Tests

Protozoan Proteins

Recombinant Proteins

Source

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Identifiers

PMID: 25223993
DOI: 10.1128/AAC.02900-14
PMCID: PMC4249547

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