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Article

The phosphate exporter xpr1b is required for differentiation of tissue-resident macrophages.

Cell reports - 25 Sept 2014

Meireles Ana M, Shiau Celia E, Guenther Catherine A, Sidik Harwin, Kingsley David M, Talbot William S

Abstract excerpt

Phosphate concentration is tightly regulated at the cellular and organismal levels. The first metazoan phosphate exporter, XPR1, was recently identified, but its in vivo function remains unknown. In a genetic screen, we identified a mutation in a zebrafish ortholog of human XPR1, xpr1b. xpr1b mutants lack microglia, the specialized macrophages that reside in the brain, and also displayed an osteopetrotic...

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Share to Bone Development
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, G-Protein-Coupled

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Source

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Identifiers

PMID: 25220463
DOI: 10.1016/j.celrep.2014.08.018
PMCID: PMC4177277

Genes

XPR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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