Article
A novel fluorescent sensor protein for detecting changes in airway surface liquid glucose concentration.
The Biochemical journal - 1 Dec 2014
Helassa Nordine, Garnett James P, Farrant Matthew, Khan Faaizah, Pickup John C, Hahn Klaus M, MacNevin Christopher J, Tarran Robert, Baines Deborah L
Abstract excerpt
Both lung disease and elevation of blood glucose are associated with increased glucose concentration (from 0.4 to ~4.0 mM) in the airway surface liquid (ASL). This perturbation of ASL glucose makes the airway more susceptible to infection by respiratory pathogens. ASL is minute (~1 μl/cm(2)) and the measurement of glucose concentration in the small volume ASL is extremely difficult. Therefore, we sought to...
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