Article
Profiling the mitochondrial proteome of Leber's Hereditary Optic Neuropathy (LHON) in Thailand: down-regulation of bioenergetics and mitochondrial protein quality control pathways in fibroblasts with the 11778G>A mutation.
PloS one - 1 Jan 2014
Tun Aung Win, Chaiyarit Sakdithep, Kaewsutthi Supannee, Katanyoo Wanphen, Chuenkongkaew Wanicha, Kuwano Masayoshi, Tomonaga Takeshi, Peerapittayamongkol Chayanon, Thongboonkerd Visith, Lertrit Patcharee
Abstract excerpt
Leber's Hereditary Optic Neuropathy (LHON) is one of the commonest mitochondrial diseases. It causes total blindness, and predominantly affects young males. For the disease to develop, it is necessary for an individual to carry one of the primary mtDNA mutations 11778G>A, 14484T>C or 3460G>A. How...
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