Article
Impact of EGFR mutation detection methods on the efficacy of erlotinib in patients with advanced EGFR-wild type lung adenocarcinoma.
PloS one - 1 Jan 2014
Tseng Jeng-Sen, Wang Chih-Liang, Huang Ming-Shyan, Chen Chung-Yu, Chang Cheng-Yu, Yang Tsung-Ying, Tsai Chi-Ren, Chen Kun-Chieh, Hsu Kuo-Hsuan, Tsai Meen-Hsin, Yu Sung-Liang, Su Kang-Yi, Wu Chih-Wei, Yang Cheng-Ta, Chen Yuh-Min, Chang Gee-Chen
Abstract excerpt
INTRODUCTION: Methods used for epidermal growth factor receptor (EGFR) mutation testing vary widely. The impact of detection methods on the rates of response to EGFR-tyrosine kinase inhibitors (TKIs) in EGFR-wild type (wt) lung adenocarcinoma patients is unknown. METHODS: We recruited the Group-I patients to evaluate the efficacy of erlotinib in patients with EGFR-wt lung adenocarcinoma by either direct...
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