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Expression of <scp>IL</scp>‐33 and its epigenetic regulation in multiple sclerosis

29 Mar 2014

Abstract excerpt

Abstract Objective We examined the expression of IL‐33 as an indicator of an innate immune response in relapsing remitting MS (RRMS) and controls. We proposed a link between the expression of IL‐33 and IL‐33 regulated genes to histone deacetylase (HDAC) activity and in particular HDAC3, an enzyme that plays a role in the epigenetic regulation of a number genes including those which regulate inflammation. Methods...

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PMID: 25215310
DOI: 10.1002/acn3.47

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