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Article

An association between single nucleotide polymorphisms within TLR and TREM-1 genes and infective endocarditis.

Cytokine - 1 Jan 2015

Golovkin Alexey S, Ponasenko Anastasia V, Yuzhalin Arseniy E, Salakhov Ramil R, Khutornaya Maria V, Kutikhin Anton G, Rutkovskaya Natalia V, Savostyanova Yulia Yu, Barbarash Leonid S

Abstract excerpt

Infective endocarditis (IE) is an inflammatory condition of the lining of the heart chambers and valves, which is generally caused by bacteria. Toll-like receptors (TLRs) and Triggering receptor expressed on myeloid cells (TREMs) are key effectors of the innate system that play a significant role in the recognition of infectious agents, particularly, bacteria. We hypothesised that inherited variation in TLR and...

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Source

Identifiers

PMID: 25213166
DOI: 10.1016/j.cyto.2014.08.001

Genes

TLR6
TLR1
TLR2
TLR4

Provenance

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