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Article

Unkempt is negatively regulated by mTOR and uncouples neuronal differentiation from growth control.

PLoS genetics - 1 Sept 2014

Avet-Rochex Amélie, Carvajal Nancy, Christoforou Christina P, Yeung Kelvin, Maierbrugger Katja T, Hobbs Carl, Lalli Giovanna, Cagin Umut, Plachot Cedric, McNeill Helen, Bateman Joseph M

Abstract excerpt

Neuronal differentiation is exquisitely controlled both spatially and temporally during nervous system development. Defects in the spatiotemporal control of neurogenesis cause incorrect formation of neural networks and lead to neurological disorders such as epilepsy and autism. The mTOR kinase integrates signals from mitogens, nutrients and energy levels to regulate growth, autophagy and metabolism. We previously...

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Identifiers

PMID: 25210733
DOI: 10.1371/journal.pgen.1004624
PMCID: PMC4161320

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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