Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Accumulation of human-adapting mutations during circulation of A(H1N1)pdm09 influenza virus in humans in the United Kingdom.

Journal of virology - 1 Nov 2014

Elderfield Ruth A, Watson Simon J, Godlee Alexandra, Adamson Walt E, Thompson Catherine I, Dunning Jake, Fernandez-Alonso Mirian, Blumenkrantz Deena, Hussell Tracy, Zambon Maria, Openshaw Peter, Kellam Paul, Barclay Wendy S

Abstract excerpt

UNLABELLED: The influenza pandemic that emerged in 2009 provided an unprecedented opportunity to study adaptation of a virus recently acquired from an animal source during human transmission. In the United Kingdom, the novel virus spread in three temporally distinct waves between 2009 and 2011. Phylogenetic analysis of complete viral genomes showed that mutations accumulated over time. Second- and third-wave...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Biological
Share to Influenza A Virus, H1N1 Subtype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza, Human

Share to Interferons

Share to Orthomyxoviridae Infections

Share to United Kingdom

Share to Virus Attachment

Source

Open in PubMed Open full text

Identifiers

PMID: 25210166
DOI: 10.1128/JVI.01636-14
PMCID: PMC4249111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Accumulation of human-adapting mutations during circulation of A(H1N1)pdm09 influenza virus in humans in the United Kingdom.PMID 25210166Read ↗

The evolution of human influenza virusesSemantic proximity Read ↗

PA Mutations Inherited during Viral Evolution Act Cooperatively To Increase Replication of Contemporary H5N1 Influenza Virus with an Expanded Host Range.Semantic proximity Read ↗

A new look at an old virus: patterns of mutation accumulation in the human H1N1 influenza virus since 1918.Semantic proximity Read ↗

Evolutionary pathways of the pandemic influenza A (H1N1) 2009 in the UK.Semantic proximity Read ↗

Characterization of the 1918 influenza virus polymerase genes.Semantic proximity Read ↗

Genomic Signatures for Avian H7N9 Viruses Adapting to Humans.Semantic proximity Read ↗

Mammalian Pathogenesis and Transmission of H7N9 Influenza Viruses from Three Waves, 2013-2015.Semantic proximity Read ↗

Functional Evolution of the 2009 Pandemic H1N1 Influenza Virus NS1 and PA in HumansSemantic proximity Read ↗

Evolutionary genotypes of influenza A (H7N9) viruses over five epidemic waves in China.Semantic proximity Read ↗

Evolution of 2009 H1N1 influenza viruses during the pandemic correlates with increased viral pathogenicity and transmissibility in the ferret modelSemantic proximity Read ↗

Recent Human Influenza A/H3N2 Virus Evolution Driven by Novel Selection Factors in Addition to Antigenic DriftSemantic proximity Read ↗

Adaptive Mutations That Occurred during Circulation in Humans of H1N1 Influenza Virus in the 2009 Pandemic Enhance Virulence in Mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.