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Dramatic response of a BRAF V600E-mutated primary CNS histiocytic sarcoma to vemurafenib

11 Sept 2014

Abstract excerpt

Histiocytic sarcoma (HS) is classified within the malignant histiocytic disorders.1 Involvement of isolated CNS in HS, termed primary CNS-HS (PCNS-HS), is characterized by a proliferation of cells in the monocyte/macrophage lineage within the CNS.2–6 This case report documents the clinical, biological, pathologic, and radiologic spectrums of PCNS-HS. Acknowledgment: The authors thank Groupe Français d’Etude des...

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PMID: 25209580
DOI: 10.1212/wnl.0000000000000880

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