Article
Primary Rosai-Dorfman disease of the central nervous system: A clinical, histological, and molecular appraisal.
Neuropathology : official journal of the Japanese Society of Neuropathology - 1 Oct 2024
Parkhi Mayur, Chatterjee Debajyoti, Kashyap Dharambir, Aggarwal Ashish, Radotra Bishan
Abstract excerpt
Rosai-Dorfman disease (RDD) is characterized by clonal proliferation of S-100 positive histiocytes and variable emperipolesis. It commonly affects cervical lymph nodes. Central nervous system (CNS) involvement is extremely rare. We attempted to evaluate the Cyclin D1 expression and frequency of KRAS and BRAF mutations in the RDD involving the CNS. All patients with histopathologically diagnosed RDD involving CNS...
Topics
- Humans
- Histiocytosis, Sinus
- Male
- Female
- Adult
- Proto-Oncogene Proteins B-raf
- Middle Aged
- Proto-Oncogene Proteins p21(ras)
- Young Adult
- Mutation
- Cyclin D1