Article
Copy number variation of GATA4 and NKX2-5 in Chinese fetuses with congenital heart disease.
Pediatrics international : official journal of the Japan Pediatric Society - 1 Apr 2015
Liu Zhen, Wang Jing, Liu Shanling, Deng Ying, Liu Hongqian, Li Nana, Li Shengli, Chen Xinlin, Lin Yuan, Wang He, Zhu Jun
Abstract excerpt
BACKGROUND: Congenital heart disease (CHD) is one of the most common birth defects in newborns. The etiology of CHD has remained largely unknown, but it is assumed to result from the combined effects of genetic and environmental factors. Recent investigations have detected potentially pathogenic copy number variations (CNV) in a proportion of patients with CHD. The present case-control study evaluated whether CNV...
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