Article
Decoy receptor CXCR7 modulates adrenomedullin-mediated cardiac and lymphatic vascular development.
Developmental cell - 8 Sept 2014
Klein Klara R, Karpinich Natalie O, Espenschied Scott T, Willcockson Helen H, Dunworth William P, Hoopes Samantha L, Kushner Erich J, Bautch Victoria L, Caron Kathleen M
Abstract excerpt
Atypical 7-transmembrane receptors, often called decoy receptors, act promiscuously as molecular sinks to regulate ligand bioavailability and consequently temper the signaling of canonical G protein-coupled receptor (GPCR) pathways. Loss of mammalian CXCR7, the most recently described decoy receptor, results in postnatal lethality due to aberrant cardiac development and myocyte hyperplasia. Here, we provide the...
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