A novel polymorphism of the GP78 gene is associated with coronary artery disease in Han population in China.

doi:10.1186/1476-511X-13-147

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Article

A novel polymorphism of the GP78 gene is associated with coronary artery disease in Han population in China.

Lipids in health and disease - 9 Sept 2014

Cha Erdenbat, Fu Zhen-Yan, Ma Yi-Tong, Zhu Qing, Xie Xiang, Liu Fen

Abstract excerpt

BACKGROUND: GP78 is a membrane-anchored ubiquitin ligase mediating the degradation of 3-hydroxy-3-methyl-glutaryl-CoA coenzyme A reductase (HMGCR) and Insig-1, which was very essential for the synthesis of cholesterol process. Cholesterol levels have a causal role in the development of cardiovascular disease. The aim of the present study was to assess the association between the human gp78 gene polymorphism and...

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Identifiers

PMID: 25200441
DOI: 10.1186/1476-511X-13-147
PMCID: PMC4175632

Genes

CAD
HMGCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.