Article
In Vitro selection of Neisseria gonorrhoeae mutants with elevated MIC values and increased resistance to cephalosporins.
Antimicrobial agents and chemotherapy - 1 Nov 2014
Johnson Steven R, Grad Yonatan, Ganakammal Satishkumar Ranganathan, Burroughs Mark, Frace Mike, Lipsitch Marc, Weil Ryan, Trees David
Abstract excerpt
Strains of Neisseria gonorrhoeae with mosaic penA genes bearing novel point mutations in penA have been isolated from ceftriaxone treatment failures. Such isolates exhibit significantly higher MIC values to third-generation cephalosporins. Here we report the in vitro isolation of two mutants with elevated MICs to cephalosporins. The first possesses a point mutation in the transpeptidase region of the mosaic penA...
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