Article
Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.
Nature communications - 8 Sept 2014
Kumar Vinod, Cheng Shih-Chin, Johnson Melissa D, Smeekens Sanne P, Wojtowicz Agnieszka, Giamarellos-Bourboulis Evangelos, Karjalainen Juha, Franke Lude, Withoff Sebo, Plantinga Theo S, van de Veerdonk Frank L, van der Meer Jos W M, Joosten Leo A B, Bochud Pierre-Yves, Marchetti Oscar, Perfect John R, Xavier Ramnik, Kullberg Bart Jan, Wijmenga Cisca, Netea Mihai G
Abstract excerpt
Candidaemia is the fourth most common cause of bloodstream infection, with a high mortality rate of up to 40%. Identification of host genetic factors that confer susceptibility to candidaemia may aid in designing adjunctive immunotherapeutic strategies. Here we hypothesize that variation in immune genes may predispose to candidaemia. We analyse 118,989 single-nucleotide polymorphisms (SNPs) across 186 loci known...
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