Article
Combined impact of hepatitis C virus genotype 1 and interleukin-6 and tumor necrosis factor-α polymorphisms on serum levels of pro-inflammatory cytokines in Brazilian HCV-infected patients.
Human immunology - 1 Nov 2014
Tarragô Andréa Monteiro, da Costa Allyson Guimarães, Pimentel João Paulo Diniz, Gomes Samara Tatielle Monteiro, Freitas Felipe Bonfim, Lalwani Pritesh, de Araújo Ana Ruth S, Victória Flamir da Silva, Victória Marilú Barbieri, Vallinoto Antônio Carlos Rosário, Sadahiro Aya, Teixeira-Carvalho Andréa, Martins-Filho Olindo Assis, Malheiro Adriana
Abstract excerpt
We investigated the association between hepatitis C virus (HCV) genotypes and host cytokine gene polymorphisms and serum cytokine levels in patients with chronic hepatitis C. Serum IL-6, TNF-α, IL-2, IFN-γ, IL-4, IL-10, and IL-17A levels were measured in 67 HCV patients (68.2% genotype 1 [G1]) and 47 healthy controls. The HCV patients had higher IL-6, IL-2, IFN-γ, IL-10, and IL-17A levels than the controls. HCV...
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