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Article

Influence of COMT genotype and affective distractors on the processing of self-generated thought.

Social cognitive and affective neuroscience - 1 Jun 2015

Kilford Emma J, Dumontheil Iroise, Wood Nicholas W, Blakemore Sarah-Jayne

Abstract excerpt

The catechol-O-methyltransferase (COMT) enzyme is a major determinant of prefrontal dopamine levels. The Val(158)Met polymorphism affects COMT enzymatic activity and has been associated with variation in executive function and affective processing. This study investigated the effect of COMT genotype on the flexible modulation of the balance between processing self-generated and processing stimulus-oriented...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25190703
DOI: 10.1093/scan/nsu118
PMCID: PMC4305337

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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