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Article

MYC activates stem-like cell potential in hepatocarcinoma by a p53-dependent mechanism.

Cancer research - 15 Oct 2014

Akita Hirofumi, Marquardt Jens U, Durkin Marian E, Kitade Mitsuteru, Seo Daekwan, Conner Elizabeth A, Andersen Jesper B, Factor Valentina M, Thorgeirsson Snorri S

Abstract excerpt

Activation of c-MYC is an oncogenic hallmark of many cancers, including liver cancer, and is associated with a variety of adverse prognostic characteristics. Despite a causative role during malignant transformation and progression in hepatocarcinogenesis, consequences of c-MYC activation for the biology of hepatic cancer stem cells (CSC) are undefined. Here, distinct levels of c-MYC overexpression were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25189530
DOI: 10.1158/0008-5472.CAN-14-0527
PMCID: PMC4199878

Genes

MYC
NANOG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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