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Article

Oncogene-specific formation of chemoresistant murine hepatic cancer stem cells

13 Apr 2012

Abstract excerpt

UNLABELLED: At least some cancer stem cells (CSCs) display intrinsic drug resistance that may thwart eradication of a malignancy by chemotherapy. We explored the genesis of such resistance by studying mouse models of liver cancer driven by either MYC or the combination of oncogenic forms of activation of v-akt murine thymoma viral oncogene homolog (AKT) and NRAS. A common manifestation of chemoresistance in CSCs...

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Identifiers

PMID: 22505225
DOI: 10.1002/hep.25776

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