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Positive Feedback Loop of OCT4 and c-JUN Expedites Cancer Stemness in Liver Cancer

24 Jun 2016

Abstract excerpt

The network of stemness genes and oncogenes in human patient-specific reprogrammed cancer stem cells (CSCs) remains elusive, especially in liver cancer. HepG2-derived induced pluripotent stem cell-like cells (HepG2-iPS-like cells) were generated by introducing Yamanaka factors and the knockdown vector shTP53. They exhibited features of stemness and a higher tumorigenesis after xenograft transplantation compared...

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PMID: 27341307
DOI: 10.1002/stem.2447

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