Article
A Novel Function for KLF4 in Modulating the De-differentiation of EpCAM-/CD133- nonStem Cells into EpCAM+/CD133+ Liver Cancer Stem Cells in HCC Cell Line HuH7.
Cells - 12 May 2020
Karagonlar Zeynep Firtina, Akbari Soheil, Karabicici Mustafa, Sahin Eren, Avci Sanem Tercan, Ersoy Nevin, Ates Kıvılcım Eren, Balli Tugsan, Karacicek Bilge, Kaplan Kubra Nur, Celiker Canan, Atabey Nese, Erdal Esra
Abstract excerpt
The complex and heterogeneous nature of hepatocellular carcinoma (HCC) hampers the identification of effective therapeutic strategies. Cancer stem cells (CSCs) represent a fraction of cells within tumors with the ability to self-renew and differentiate, and thus significantly contribute to the formation and maintenance of heterogeneous tumor mass. Increasing evidence indicates high plasticity in tumor cells,...
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