Article
Pre-miR-146a (rs2910164 G>C) single nucleotide polymorphism is genetically and functionally associated with leprosy.
PLoS neglected tropical diseases - 1 Sept 2014
Cezar-de-Mello Paula F T, Toledo-Pinto Thiago G, Marques Carolinne S, Arnez Lucia E A, Cardoso Cynthia C, Guerreiro Luana T A, Antunes Sérgio L G, Jardim Márcia M, Covas Claudia de J F, Illaramendi Ximena, Dias-Baptista Ida M, Rosa Patrícia S, Durães Sandra M B, Pacheco Antonio G, Ribeiro-Alves Marcelo, Sarno Euzenir N, Moraes Milton O
Abstract excerpt
Mycobacterium leprae infects macrophages and Schwann cells inducing a gene expression program to facilitate its replication and progression to disease. MicroRNAs (miRNAs) are key regulators of gene expression and could be involved during the infection. To address the genetic influence of miRNAs in leprosy, we enrolled 1,098 individuals and conducted a case-control analysis in order to study four miRNAs genes...
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