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Article

Functional changes in pulmonary arterial endothelial cells associated with BMPR2 mutations.

PloS one - 1 Jan 2014

Wang Hu, Ji Ruirui, Meng Jie, Cui Qiqiong, Zou Wenxin, Li Lei, Wang Guoliang, Sun Li, Li Zhaohui, Huo Lei, Fan Yuxin, Penny Daniel J

Abstract excerpt

Pulmonary arterial hypertension (PAH) is a devastating disease characterized by abnormal remodeling of small, peripheral pulmonary arteries. Germline mutations in the bone morphogenetic protein receptor type 2 (BMPR2) gene are a major risk factor for developing PAH. At present, the correlation between the BMPR2 mutation and the patient's prognosis remains controversial despite several investigations. In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25187962
DOI: 10.1371/journal.pone.0106703
PMCID: PMC4154762

Genes

BMPR2
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Consequences of BMPR2 Deficiency in the Pulmonary Vasculature and Beyond: Contributions to Pulmonary Arterial Hypertension.Semantic proximity Read ↗

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