Article
Analysis of the conformation of the androgen receptor in spinal bulbar muscular atrophy by atomic force microscopy.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014
Jochum Tobias, Cato Andrew C B
Abstract excerpt
Spinal bulbar muscular atrophy (SBMA) (also known as Kennedy's disease) is a motor degenerative disease caused by an amplification of the polyglutamine stretch at the N-terminus of the human androgen receptor (AR). Amplifications larger than 40 glutamine residues are thought to lead to the diseas...
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