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Article

Analysis of the conformation of the androgen receptor in spinal bulbar muscular atrophy by atomic force microscopy.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014

Jochum Tobias, Cato Andrew C B

Abstract excerpt

Spinal bulbar muscular atrophy (SBMA) (also known as Kennedy's disease) is a motor degenerative disease caused by an amplification of the polyglutamine stretch at the N-terminus of the human androgen receptor (AR). Amplifications larger than 40 glutamine residues are thought to lead to the disease. A characteristic feature of this disease is a ligand-dependent misfolding and aggregation of the mutant receptor...

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Identifiers

PMID: 25182772
DOI: 10.1007/978-1-4939-1346-6_17

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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