Article

CRISPR-Cas9 Guided RNA Based Model for the Silencing of Spinal Bulbar Muscular Atrophy: A Functional Genetic Disorder

2023-01-30

Abstract excerpt

Spinal bulbar muscular atrophy (SBMA) is a neurodegenerative genetic disorder, which results because of a mutation in the start codon of the Androgen Receptor (AR) gene. The mutant Androgen Receptor gene features the polyglutamine expansion (CAG) repeats, undergoing inappropriate post-translational modifications, which leads to development of toxin production functionality. In order to inhibit the production of mu...

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Literature Corpus work: 5477bd13-c0b2-57b9-a355-84cbf221c9eb
DOI: 10.22541/au.167507492.27431039/v1

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