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Article

Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion.

Journal of experimental & clinical cancer research : CR - 2 Sept 2014

Li Juan, Liu Jie, Li Pingping, Mao Xiaona, Li Wenjie, Yang Jin, Liu Peijun

Abstract excerpt

BACKGROUND: LKB1, also known as STK11, is a master kinase that serves as an energy metabolic sensor and is involved in cell polarity regulation. Recent studies have indicated that LKB1 is related to breast tumorigenesis and breast cancer progression. However, little work has been done on the roles of LKB1 in cell polarity and epithelial-mesenchymal transition in breast cancer. In this study, we tried to prove...

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Topics

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Share to AMP-Activated Protein Kinase Kinases
Share to Cell Polarity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Epithelial-Mesenchymal Transition

Share to Gene Expression Regulation, Enzymologic

Share to Mammary Glands, Human

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Share to Neoplasm Invasiveness

Source

Open in PubMed Open full text

Identifiers

PMID: 25178656
DOI: 10.1186/s13046-014-0070-0
PMCID: PMC4431490

Genes

STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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