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Article

High prevalence of deficient mismatch repair phenotype and the V600E BRAF mutation in elderly patients with colorectal cancer.

Journal of geriatric oncology - 1 Oct 2014

Aparicio Thomas, Schischmanoff Olivier, Poupardin Cecile, Mary Florence, Soufir Nadem, Barrat Christophe, Bellaiche Guy, Boubaya Marouane, Choudat Laurence, Cucherousset Joel, DesGuetz Gaetan, Wind Philippe, Benamouzig Robert

Abstract excerpt

AIMS: Colorectal cancer (CRC) occurs mostly in the elderly. However, the biology of CRC in elderly has been poorly studied. This study examined the prevalence of deficient mismatch repair phenotype (dMMR) and BRAF mutations according to age. PATIENTS AND METHODS: MMR phenotype was prospectively determined by molecular analysis in patients of all ages undergoing surgery for CRC. BRAF V600E mutation status was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25176643
DOI: 10.1016/j.jgo.2014.08.002

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BRAF

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