Article
Defective B-cell proliferation and maintenance of long-term memory in patients with chronic granulomatous disease.
The Journal of allergy and clinical immunology - 1 Mar 2015
Cotugno Nicola, Finocchi Andrea, Cagigi Alberto, Di Matteo Gigliola, Chiriaco Maria, Di Cesare Silvia, Rossi Paolo, Aiuti Alessandro, Palma Paolo, Douagi Iyadh
Abstract excerpt
BACKGROUND: Chronic granulomatous disease (CGD) is a primary immune deficiency characterized by a defect in reactive oxygen species production. Although the effect of CGD mainly reflects on the phagocytic compartment, B-cell responses are also impaired in patients with CGD. OBJECTIVE: We sought to investigate how defective gp91(phox) expression in patients with CGD and CGD carriers might affect the B-cell...
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