Article
RVboost: RNA-seq variants prioritization using a boosting method.
Bioinformatics (Oxford, England) - 1 Dec 2014
Wang Chen, Davila Jaime I, Baheti Saurabh, Bhagwate Aditya V, Wang Xue, Kocher Jean-Pierre A, Slager Susan L, Feldman Andrew L, Novak Anne J, Cerhan James R, Thompson E Aubrey, Asmann Yan W
Abstract excerpt
MOTIVATION: RNA-seq has become the method of choice to quantify genes and exons, discover novel transcripts and detect fusion genes. However, reliable variant identification from RNA-seq data remains challenging because of the complexities of the transcriptome, the challenges of accurately mapping exon boundary spanning reads and the bias introduced during the sequencing library preparation. METHOD: We developed...
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