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Article

FVC as an adaptive and accurate method for filtering variants from popular NGS analysis pipelines.

Communications biology - 16 Sept 2022

Ren Yongyong, Kong Yan, Zhou Xiaocheng, Genchev Georgi Z, Zhou Chao, Zhao Hongyu, Lu Hui

Abstract excerpt

The quality control of variants from whole-genome sequencing data is vital in clinical diagnosis and human genetics research. However, current filtering methods (Frequency, Hard-Filter, VQSR, GARFIELD, and VEF) were developed to be utilized on particular variant callers and have certain limitations. Especially, the number of eliminated true variants far exceeds the number of removed false variants using these...

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PMID: 36114280
DOI: 10.1038/s42003-022-03397-7
PMCID: PMC9481582

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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