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Article

An efficient and scalable analysis framework for variant extraction and refinement from population-scale DNA sequence data.

Genome research - 1 Jun 2015

Jun Goo, Wing Mary Kate, Abecasis Gonçalo R, Kang Hyun Min

Abstract excerpt

The analysis of next-generation sequencing data is computationally and statistically challenging because of the massive volume of data and imperfect data quality. We present GotCloud, a pipeline for efficiently detecting and genotyping high-quality variants from large-scale sequencing data. GotCloud automates sequence alignment, sample-level quality control, variant calling, filtering of likely artifacts using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25883319
DOI: 10.1101/gr.176552.114
PMCID: PMC4448687

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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