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Article

Molecular Pathways: Autophagy in Cancer—A Matter of Timing and Context

28 Aug 2014

Abstract excerpt

Autophagy is an intracellular self-digestion mechanism, by which cellular components are sorted into double-membrane autophagosomes and delivered to lysosomes for degradation. Cells use autophagy to dispose of wastes and eliminate hazards, while recycling nutrients and tuning metabolism in the process. Through these functions, autophagy promotes cell fitness, genome integrity, tissue homeostasis, and cell...

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PMID: 25165101
DOI: 10.1158/1078-0432.ccr-13-2438

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