Article
Evolutionary consequences of intra-patient phage predation on microbial populations.
eLife - 26 Aug 2014
Seed Kimberley D, Yen Minmin, Shapiro B Jesse, Hilaire Isabelle J, Charles Richelle C, Teng Jessica E, Ivers Louise C, Boncy Jacques, Harris Jason B, Camilli Andrew
Abstract excerpt
The impact of phage predation on bacterial pathogens in the context of human disease is not currently appreciated. Here, we show that predatory interactions of a phage with an important environmentally transmitted pathogen, Vibrio cholerae, can modulate the evolutionary trajectory of this pathogen during the natural course of infection within individual patients. We analyzed geographically and temporally...
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