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Article

Positive selection during the evolution of the blood coagulation factors in the context of their disease-causing mutations.

Molecular biology and evolution - 1 Nov 2014

Rallapalli Pavithra M, Orengo Christine A, Studer Romain A, Perkins Stephen J

Abstract excerpt

Blood coagulation occurs through a cascade of enzymes and cofactors that produces a fibrin clot, while otherwise maintaining hemostasis. The 11 human coagulation factors (FG, FII-FXIII) have been identified across all vertebrates, suggesting that they emerged with the first vertebrates around 500 Ma. Human FVIII, FIX, and FXI are associated with thousands of disease-causing mutations. Here, we evaluated the...

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Identifiers

PMID: 25158795
DOI: 10.1093/molbev/msu248
PMCID: PMC4209140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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