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Article

Enzymatic desymmetrising redox reactions for the asymmetric synthesis of biaryl atropisomers.

Chemistry (Weinheim an der Bergstrasse, Germany) - 6 Oct 2014

Staniland Samantha, Yuan Bo, Giménez-Agulló Nelson, Marcelli Tommaso, Willies Simon C, Grainger Damian M, Turner Nicholas J, Clayden Jonathan

Abstract excerpt

Atropisomeric biaryls carrying ortho-hydroxymethyl and formyl groups were made enantioselectively by desymmetrisation of dialdehyde or diol substrates. The oxidation of the symmetrical diol substrates was achieved using a variant of galactose oxidase (GOase), and the reduction of the dialdehydes using a panel of ketoreductases. Either M or P enantiomers of the products could be formed, with absolute...

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Identifiers

PMID: 25156181
DOI: 10.1002/chem.201404509
PMCID: PMC4497317

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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